Slay the Spire 2 character mod

The Alchemist

The Alchemist is a new character for Slay the Spire 2: a curious frog who will drink anything once, on a personal journey through the Spire. They balance their own poison to quickly get stronger, mix up potion-like cards during combat while letting other cards ferment in hand until they’re ready, and brew special potions at Rest Sites that can be sold to the Merchant.

See mechanics
  • Poison: The Alchemist doses themselves on purpose. Some attacks deal more damage the more Poison you have, and other cards trigger every time your Poison does. There are also many ways to apply Poison to enemies.
  • Antitoxin: Protects you from your own Poison. Each time your Poison triggers, Antitoxin prevents up to that much damage. It isn’t used up, but it goes down by 1 at the start of each turn just like Poison.
  • Mixes: 0-cost cards you create in combat that have effects similar to potions. The basic Mixes are Bursting (damage), Syrupy (Block) and Zesty (draw). The volatile Mixes are Fuming (damage to all enemies and Tainted), Acrid (Weak and Vulnerable) and Sparkling (Energy).
  • Ferment: These cards Retain and get more potent for every turn they stay in your hand. There are ways to manipulate these Fermentation levels to gain an edge.
  • Brew: A new Rest Site option that upgrades a random card in your deck and lets you choose 1 of 3 special potions. Due to the quality of these brews, the Merchant is willing to buy them from you for 100 Gold.
  • 123 cards
  • 9 relics
  • 11 potions
  • 7 timeline epochs

Latest: v0.15.5 patch notes, Nov 3, 2026. Stats from 18,292 runs by 5,444 players, updated every day.

This mod is still a work in progress and content is subject to change, but feedback is welcome! The best place to talk about the mod is the Alchemist post in #modding-forum on the official Slay the Spire Discord server.

Language translations are auto-generated for now. The plan is to commission native translators once the content changes slow down. In the meantime, corrections are appreciated! If you see an error in your language, please contact me or feel free to open a pull request on GitHub.

Cards

123 cards

Card stats

Starting deck 4 cards

Common 20 cards

Uncommon 37 cards

Rare 28 cards

Ancient 2 cards

Created in combat 7 cards

The Hero Expansion 11 cards

Reshuffled Spire 11 cards

Ancients Awakened 3 cards

Filter and sort